Essential Lab Testing for Women’s Health: A Practitioner’s Guide Through Premenopause, Perimenopause & Menopause with Practice Better & Fullscript

Written by
Practice Better
Emma Benner
Published on
July 30, 2025

Disclaimer: The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

Approximately 75% of women experience hot flashes or night sweats during menopause, yet fewer than half seek professional care — a clear gap that highlights the importance of proactive, informed clinical support through lab testing (PMC).

Navigating women's health across hormonal life stages can feel complex. From cycle irregularities and mood shifts to metabolic changes and bone health, symptoms often overlap or evolve in subtle ways. As practitioners, our role is to bring clarity. Lab testing gives us the insight we need to support patients with precision and confidence.

In this blog, you’ll learn which lab tests are most valuable at each stage — premenopause, perimenopause, and menopause — how to interpret them in clinical context, and how to seamlessly integrate lab testing into your workflow using Practice Better and Fullscript.

Understanding premenopause: Establishing baseline health

Clients in premenopause may not yet show overt hormonal symptoms but often present with issues like fatigue, mood fluctuations, or weight changes. These cases benefit from foundational testing, including:

  • TSH, Free T4, Free T3 to screen for thyroid dysfunction
  • Vitamin D, fasting insulin, and fasting glucose to assess immune and metabolic status
  • Estradiol on Cycle Day 3, which serves as a benchmark for monitoring hormonal changes over time

These labs create a baseline for individual health patterns, enabling earlier identification of dysregulation before more pronounced shifts begin.

Perimenopause: Interpreting fluctuating hormones

Perimenopause, which commonly begins in the early 40s, can span several years and is often marked by fluctuating symptoms such as sleep disruption, mood instability, and irregular menstrual cycles (NIH, TIME).

During this time, consider:

  • FSH and LH: Levels may spike or fall unpredictably and must be interpreted alongside clinical presentation
  • Anti-Müllerian Hormone (AMH): A marker of ovarian reserve
  • Mid-luteal Estradiol and Progesterone: Offers clarity on luteal phase hormone production

Because hormone levels vary significantly day to day, focusing on patterns over time — not isolated values — improves diagnostic accuracy.

Menopause: Monitoring long-term risk factors

Menopause is clinically diagnosed after 12 consecutive months without menstruation, typically around age 51 (MiraCare). Testing at this stage shifts from diagnosis to risk management and ongoing monitoring.

Recommended labs include:

  • FSH >30 mIU/mL and Estradiol <20 pg/mL, confirming ovarian shutdown (Proov, Healthline)
  • Lipid panel, fasting glucose, fasting insulin, A1C, and hs-CRP to evaluate cardiovascular and metabolic risk
  • Bone turnover markers such as osteocalcin or NTx to track bone density loss

These labs help practitioners proactively address emerging health risks rather than reacting to symptoms alone.

The clinical value of stage-specific lab testing

Lab testing empowers practitioners to:

  • Clarify the underlying cause of symptoms — whether hormonal, metabolic, or thyroid-related
  • Personalize treatment plans with data-driven decisions
  • Track patient progress and treatment response over time

It also enhances trust — when clients see measurable results, they’re more likely to stay engaged and compliant.

Streamlining lab workflows: Practice Better + Fullscript integration

For U.S.-based practitioners, the integration between Practice Better and Fullscript streamlines the lab ordering and results management process.

Once your accounts are linked, you can:

  • Order labs directly from within a client’s Practice Better record
  • Push orders to Fullscript for processing
  • Receive results automatically in Practice Better, ready for annotation and discussion

This integration consolidates your workflow, allowing more time for meaningful patient care.

A simple workflow, start to finish

  1. Link your Fullscript account in Practice Better under 3rd-Party Integrations
  2. Create a lab order within the client’s file
  3. Choose the lab tests and submit via Fullscript
  4. Once processed, the results sync back to Practice Better
  5. Annotate results, share findings, and plan next steps — all in one place

The result is a smoother experience for both practitioner and client.

Efficiency, engagement, and growth

Beyond convenience, this integration supports:

  • Operational efficiency through unified documentation
  • Improved client outcomes via consistent monitoring
  • Stronger team collaboration by enabling shared dispensaries or practitioner roles

Ready to get started?

If you’re looking to simplify lab workflows and deepen clinical insight, activating the labs on Fullscript integration is a smart move. Here’s how to get started.

Try it this week: select one client, order a relevant lab, and walk through the process. You’ll be surprised how much easier it makes your clinical day.

Final thoughts

From subtle hormonal shifts in premenopause to chronic disease risk during menopause, lab testing is one of the most powerful tools in a practitioner’s toolkit. When paired with a streamlined system like Practice Better + Fullscript, it becomes even more valuable.

Take the first step today. Help your clients understand their health on a deeper level — and take action with confidence.

Frequently asked questions

What lab tests are helpful for perimenopause?

Consider FSH, estradiol, and progesterone, especially when tested across multiple cycles and tied to symptoms.

Can I annotate lab results directly in Practice Better?

Yes. Once synced from Fullscript, results can be annotated, discussed, and shared — all within the client’s portal.

Is labs on Fullscript available in Canada?

No, labs on Fullscript is currently only available to practitioners based in the U.S.

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Essential Lab Testing for Women’s Health: A Practitioner’s Guide Through Premenopause, Perimenopause & Menopause with Practice Better & Fullscript

Disclaimer: The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.

Approximately 75% of women experience hot flashes or night sweats during menopause, yet fewer than half seek professional care — a clear gap that highlights the importance of proactive, informed clinical support through lab testing (PMC).

Navigating women's health across hormonal life stages can feel complex. From cycle irregularities and mood shifts to metabolic changes and bone health, symptoms often overlap or evolve in subtle ways. As practitioners, our role is to bring clarity. Lab testing gives us the insight we need to support patients with precision and confidence.

In this blog, you’ll learn which lab tests are most valuable at each stage — premenopause, perimenopause, and menopause — how to interpret them in clinical context, and how to seamlessly integrate lab testing into your workflow using Practice Better and Fullscript.

Understanding premenopause: Establishing baseline health

Clients in premenopause may not yet show overt hormonal symptoms but often present with issues like fatigue, mood fluctuations, or weight changes. These cases benefit from foundational testing, including:

  • TSH, Free T4, Free T3 to screen for thyroid dysfunction
  • Vitamin D, fasting insulin, and fasting glucose to assess immune and metabolic status
  • Estradiol on Cycle Day 3, which serves as a benchmark for monitoring hormonal changes over time

These labs create a baseline for individual health patterns, enabling earlier identification of dysregulation before more pronounced shifts begin.

Perimenopause: Interpreting fluctuating hormones

Perimenopause, which commonly begins in the early 40s, can span several years and is often marked by fluctuating symptoms such as sleep disruption, mood instability, and irregular menstrual cycles (NIH, TIME).

During this time, consider:

  • FSH and LH: Levels may spike or fall unpredictably and must be interpreted alongside clinical presentation
  • Anti-Müllerian Hormone (AMH): A marker of ovarian reserve
  • Mid-luteal Estradiol and Progesterone: Offers clarity on luteal phase hormone production

Because hormone levels vary significantly day to day, focusing on patterns over time — not isolated values — improves diagnostic accuracy.

Menopause: Monitoring long-term risk factors

Menopause is clinically diagnosed after 12 consecutive months without menstruation, typically around age 51 (MiraCare). Testing at this stage shifts from diagnosis to risk management and ongoing monitoring.

Recommended labs include:

  • FSH >30 mIU/mL and Estradiol <20 pg/mL, confirming ovarian shutdown (Proov, Healthline)
  • Lipid panel, fasting glucose, fasting insulin, A1C, and hs-CRP to evaluate cardiovascular and metabolic risk
  • Bone turnover markers such as osteocalcin or NTx to track bone density loss

These labs help practitioners proactively address emerging health risks rather than reacting to symptoms alone.

The clinical value of stage-specific lab testing

Lab testing empowers practitioners to:

  • Clarify the underlying cause of symptoms — whether hormonal, metabolic, or thyroid-related
  • Personalize treatment plans with data-driven decisions
  • Track patient progress and treatment response over time

It also enhances trust — when clients see measurable results, they’re more likely to stay engaged and compliant.

Streamlining lab workflows: Practice Better + Fullscript integration

For U.S.-based practitioners, the integration between Practice Better and Fullscript streamlines the lab ordering and results management process.

Once your accounts are linked, you can:

  • Order labs directly from within a client’s Practice Better record
  • Push orders to Fullscript for processing
  • Receive results automatically in Practice Better, ready for annotation and discussion

This integration consolidates your workflow, allowing more time for meaningful patient care.

A simple workflow, start to finish

  1. Link your Fullscript account in Practice Better under 3rd-Party Integrations
  2. Create a lab order within the client’s file
  3. Choose the lab tests and submit via Fullscript
  4. Once processed, the results sync back to Practice Better
  5. Annotate results, share findings, and plan next steps — all in one place

The result is a smoother experience for both practitioner and client.

Efficiency, engagement, and growth

Beyond convenience, this integration supports:

  • Operational efficiency through unified documentation
  • Improved client outcomes via consistent monitoring
  • Stronger team collaboration by enabling shared dispensaries or practitioner roles

Ready to get started?

If you’re looking to simplify lab workflows and deepen clinical insight, activating the labs on Fullscript integration is a smart move. Here’s how to get started.

Try it this week: select one client, order a relevant lab, and walk through the process. You’ll be surprised how much easier it makes your clinical day.

Final thoughts

From subtle hormonal shifts in premenopause to chronic disease risk during menopause, lab testing is one of the most powerful tools in a practitioner’s toolkit. When paired with a streamlined system like Practice Better + Fullscript, it becomes even more valuable.

Take the first step today. Help your clients understand their health on a deeper level — and take action with confidence.

Frequently asked questions

What lab tests are helpful for perimenopause?

Consider FSH, estradiol, and progesterone, especially when tested across multiple cycles and tied to symptoms.

Can I annotate lab results directly in Practice Better?

Yes. Once synced from Fullscript, results can be annotated, discussed, and shared — all within the client’s portal.

Is labs on Fullscript available in Canada?

No, labs on Fullscript is currently only available to practitioners based in the U.S.

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