How to Choose the Best E-Prescribing Software

Written by
Practice Better
Emma Benner
Published on
July 22, 2025

Why e-prescribing is essential for modern care

E-prescribing is a key part of safe and modern healthcare for practices of all shapes and sizes. With paper prescriptions becoming obsolete, practitioners are adopting electronic prescribing software to minimize medication errors, improve patient adherence, and ensure compliance.

Beyond convenience, e-prescribing enhances patient safety by eliminating handwriting errors and enabling real-time drug interaction checks. In today's digital care environment, the best electronic prescription software seamlessly integrates with electronic health record (EHR) systems, supporting more coordinated, holistic care.

What is e-prescribing software (and who needs it?)

E-prescribing software enables healthcare providers to create and transmit prescriptions to a patient’s chosen pharmacy electronically, offering greater accuracy, speed, and security.

Who needs e-prescribing?

E-prescribing is essential for:

  • Physicians (MDs, DOs)
  • Nurse Practitioners (NPs)
  • Physician Assistants (PAs)
  • Other licensed prescribers

Whether you own your own solo practice or work in a group clinic setting, your e-prescribing software should improve patient outcomes, streamline operations, and ensure regulatory compliance.

Compliance and legal requirements

Modern e-prescribing solutions must meet the following legal criteria:

  • DEA’s EPCS certification for controlled substances
  • HIPAA compliance for patient privacy
  • State and federal regulations, many of which now require digital prescribing

Refer to the DEA's EPCS certification for more information.

Key features to look for

Not all e-prescribing software is created equal. Look for features that optimize safety, reduce workload, and fit seamlessly into your existing ecosystem.

Real-time prescription tracking

Track the status of prescriptions from submission to fulfillment – improving transparency and patient follow-up.

Drug interaction and allergy alerts

Built-in clinical decision support can alert you to known interactions or allergies in real time, helping prevent harmful mistakes.

EPCS and HIPAA compliance

Your platform must meet industry standards to protect patient data and authorize electronic prescribing of controlled substances.

Explore the compliance benefits on HealthIT.gov.

Access to patient medication history

Gain access to a complete medication record, helping you avoid redundant or conflicting prescriptions.

Seamless EHR integration

Choose a solution that integrates smoothly with your existing EHR to reduce double documentation and data entry errors.

Why e-prescribing is a critical part of any private practice EHR

A good EHR brings your entire clinical workflow into one place — helping you manage every step of the client care journey seamlessly. With e-prescribing, you can bring every touchpoint under one roof, managing care from intake to treatment more efficiently, compliantly, and collaboratively than ever before.

Here are some of the key things you should be looking for when evaluating EHRs with e-prescribing functionality:

Future-ready workflows

From charting and billing to scheduling, a great EHR offers a unified experience. E-prescribing completes the end-to-end clinical workflow.

Centralized medication management

Your EHR should also be equipped to track supplements and medications. E-prescribing takes it one step further, allowing you to fully manage the approval and distribution of your clients' medications. See how Practice Better lets you seamlessly track medications and supplements.

Agile, HIPAA-compliant telehealth

It may sound obvious, but your EHR should provide a fully HIPAA-compliant telehealth experience. E-prescribing further supports this virtual care delivery, allowing you to seamlessly prescribe medications for patients, even during remote sessions.

Practitioner checklist: How to evaluate software providers

When evaluating E-prescribing platforms, you can use this checklist to guide your decision.

Vendor certifications and security standards

  • DEA-certified for EPCS
  • HIPAA-compliant infrastructure
  • SOC 2 or HITRUST-certified data practices

Usability and training resources

  • Intuitive user interface
  • Comprehensive onboarding
  • Accessible help documentation and training

Support and customer reviews

  • Responsive support channels
  • Transparent product updates
  • Strong provider testimonials and case studies

Questions to ask before choosing a platform

Make sure you ask vendors:

What’s the implementation timeline?

How quickly can the system be deployed, and what onboarding support is included?

Does it integrate with my current systems?

Confirm EHR compatibility to ensure smooth adoption without workflow disruption.

What are the ongoing costs?

Understand all pricing – subscription fees, transaction costs, support charges, and potential add-ons.

The future of prescribing is here with Practice Better’s ePrescribe

ePrescribe in Practice Better isn't just a feature — it's a transformational leap in how healthcare professionals prescribe. By embedding a fully compliant, intuitive e-prescribing experience directly into your clinical workflow, we eliminate the need for faxes, manual scripts, or external portals.

Whether you’re a solo practitioner or part of a larger clinic, you can now send prescriptions in seconds, access real-time safety checks, and stay 100% compliant — all within the same platform you use to chart, schedule, and communicate with clients.

Learn more about Practice Better’s new ePrescribe feature

See how it works

This is a game-changer for modern practitioners who demand both convenience and compliance. You’ll reduce risks, reclaim time, and elevate the client experience — all while staying ahead of regulatory requirements and industry standards.

If you're searching for the best e-prescribing software that works the way you do, Practice Better’s ePrescribe is the future-forward solution you’ve been waiting for.

Start prescribing smarter, faster, and safer — all in one place.

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How to Choose the Best E-Prescribing Software

Why e-prescribing is essential for modern care

E-prescribing is a key part of safe and modern healthcare for practices of all shapes and sizes. With paper prescriptions becoming obsolete, practitioners are adopting electronic prescribing software to minimize medication errors, improve patient adherence, and ensure compliance.

Beyond convenience, e-prescribing enhances patient safety by eliminating handwriting errors and enabling real-time drug interaction checks. In today's digital care environment, the best electronic prescription software seamlessly integrates with electronic health record (EHR) systems, supporting more coordinated, holistic care.

What is e-prescribing software (and who needs it?)

E-prescribing software enables healthcare providers to create and transmit prescriptions to a patient’s chosen pharmacy electronically, offering greater accuracy, speed, and security.

Who needs e-prescribing?

E-prescribing is essential for:

  • Physicians (MDs, DOs)
  • Nurse Practitioners (NPs)
  • Physician Assistants (PAs)
  • Other licensed prescribers

Whether you own your own solo practice or work in a group clinic setting, your e-prescribing software should improve patient outcomes, streamline operations, and ensure regulatory compliance.

Compliance and legal requirements

Modern e-prescribing solutions must meet the following legal criteria:

  • DEA’s EPCS certification for controlled substances
  • HIPAA compliance for patient privacy
  • State and federal regulations, many of which now require digital prescribing

Refer to the DEA's EPCS certification for more information.

Key features to look for

Not all e-prescribing software is created equal. Look for features that optimize safety, reduce workload, and fit seamlessly into your existing ecosystem.

Real-time prescription tracking

Track the status of prescriptions from submission to fulfillment – improving transparency and patient follow-up.

Drug interaction and allergy alerts

Built-in clinical decision support can alert you to known interactions or allergies in real time, helping prevent harmful mistakes.

EPCS and HIPAA compliance

Your platform must meet industry standards to protect patient data and authorize electronic prescribing of controlled substances.

Explore the compliance benefits on HealthIT.gov.

Access to patient medication history

Gain access to a complete medication record, helping you avoid redundant or conflicting prescriptions.

Seamless EHR integration

Choose a solution that integrates smoothly with your existing EHR to reduce double documentation and data entry errors.

Why e-prescribing is a critical part of any private practice EHR

A good EHR brings your entire clinical workflow into one place — helping you manage every step of the client care journey seamlessly. With e-prescribing, you can bring every touchpoint under one roof, managing care from intake to treatment more efficiently, compliantly, and collaboratively than ever before.

Here are some of the key things you should be looking for when evaluating EHRs with e-prescribing functionality:

Future-ready workflows

From charting and billing to scheduling, a great EHR offers a unified experience. E-prescribing completes the end-to-end clinical workflow.

Centralized medication management

Your EHR should also be equipped to track supplements and medications. E-prescribing takes it one step further, allowing you to fully manage the approval and distribution of your clients' medications. See how Practice Better lets you seamlessly track medications and supplements.

Agile, HIPAA-compliant telehealth

It may sound obvious, but your EHR should provide a fully HIPAA-compliant telehealth experience. E-prescribing further supports this virtual care delivery, allowing you to seamlessly prescribe medications for patients, even during remote sessions.

Practitioner checklist: How to evaluate software providers

When evaluating E-prescribing platforms, you can use this checklist to guide your decision.

Vendor certifications and security standards

  • DEA-certified for EPCS
  • HIPAA-compliant infrastructure
  • SOC 2 or HITRUST-certified data practices

Usability and training resources

  • Intuitive user interface
  • Comprehensive onboarding
  • Accessible help documentation and training

Support and customer reviews

  • Responsive support channels
  • Transparent product updates
  • Strong provider testimonials and case studies

Questions to ask before choosing a platform

Make sure you ask vendors:

What’s the implementation timeline?

How quickly can the system be deployed, and what onboarding support is included?

Does it integrate with my current systems?

Confirm EHR compatibility to ensure smooth adoption without workflow disruption.

What are the ongoing costs?

Understand all pricing – subscription fees, transaction costs, support charges, and potential add-ons.

The future of prescribing is here with Practice Better’s ePrescribe

ePrescribe in Practice Better isn't just a feature — it's a transformational leap in how healthcare professionals prescribe. By embedding a fully compliant, intuitive e-prescribing experience directly into your clinical workflow, we eliminate the need for faxes, manual scripts, or external portals.

Whether you’re a solo practitioner or part of a larger clinic, you can now send prescriptions in seconds, access real-time safety checks, and stay 100% compliant — all within the same platform you use to chart, schedule, and communicate with clients.

Learn more about Practice Better’s new ePrescribe feature

See how it works

This is a game-changer for modern practitioners who demand both convenience and compliance. You’ll reduce risks, reclaim time, and elevate the client experience — all while staying ahead of regulatory requirements and industry standards.

If you're searching for the best e-prescribing software that works the way you do, Practice Better’s ePrescribe is the future-forward solution you’ve been waiting for.

Start prescribing smarter, faster, and safer — all in one place.

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